Coca-Cola Company Essays - Coca-Cola, Patent Medicines, Kosher Food

Coca-Cola Company The Coca-Cola company started out as an insignificant one man business and over the last one hundred and ten years it has grown into one of the largest companies in the world. The first operator of the company was Dr. John Pemberton and the current operator is Roberto Goizueta. Without societies help, Coca-Cola could not have become over a 50 billion dollar business. Coca-Cola was invented by Dr. John Pemberton, an Atlanta pharmacist. He concocted the formula in a three legged brass kettle in his backyard on May 8, 1886. He mixed a combination of lime, cinnamon, coca leaves, and the seeds of a Brazilian shrub to make the fabulous beverage. Coca-Cola debuted in Atlanta's largest pharmacy, Jacob's Pharmacy, as a five cent non-carbonated beverage, which was originally used as a nerve and brain tonic and a medical elixir. Later on, the carbonated water was added to the syrup to make the beverage that we know today as Coca-Cola. At the time of his death, John Pemberton sold the Coca-Cola company to Asa Candler, Pemberton was forced to sell because he was very ill and was in debt. Candler achieved a lot during his time as owner of the company. On January 31, 1893, the famous Coca-Cola formula was copyrighted. The first syrup manufacturing plant was opened in 1884. However, Candler's great achievement was large scale bottling of Coca-Cola in 1899. In 1915, The Root Glass Company made the contour bottle for the Coca-Cola company. Coca-Cola was sold after the Prohibition Era to Ernest Woodruff for 25 million dollars. He gave Coca-Cola to his son, Robert Woodruff, who would be president for six decades (Facts, Figures, and Features Multiple pages). Robert Woodruff was an influential man in Atlanta because of his contributions to area colleges, universities, businesses and organizations. When he made a contribution, he would never leave his name, this is how he became to be known as "Mr. Anonymous." Woodruff introduced the six bottle carton in 1923. He also made Coca-Cola available through vending machine in 1929, that same year, the Coca-Cola bell glass was made available. He started advertising on the radio in the 1930s and on the television in 1950. Currently Coca-Cola is advertised on over five hundred TV channels around the world. In 1931, he introduced the Coke Santa as a Christmas promotion and it caught on. Candler also introduced the twelve ounce Coke can in 1960. The Coca-Cola contour bottle was patented in 1977. The two liter bottle was introduced in 1978, the same year the company also introduced plastic bottles(Coca-Cola multiple pages). Woodruff did have one dubious distinction, he raised the syrup prices for distributors. But he improved efficiency at every step of the manufacturing process. Woodruff also increased productivity by improving the sales department, emphasizing quality control, and beginning large-scale advertising and promotional campaigns. Woodruff made Coke available in every state of the Union through the soda fountain. For all of these achievements he earned the name, "The Boss"(Facts, Figures, and Features Multiple pages). In 1985, the Coca-Cola Company made what has been known as one of the biggest marketing blunder. The Coca-Cola company stumbled onto the new formula in efforts to produce diet Coke. They put forth 4 million dollars of research to come up with the new formula. The decision to change their formula and pull the old Coke off the market came about because taste tests showed a distinct preference for the new formula. The new formula was a sweeter variation with less tang, it was also slightly smoother(Demott 54). Robert Woodruff's death was a large contributor to the change because he stated that he would never change Coca-Cola's formula. Another factor that influenced the change was that Coke's market share fell 2.5 percent in four years. Each percentage point lost or gain meant 200 million dollars. A financial analyst said, "Coke's market share fell from 24.3 percent in 1980 to 21.8 percent in 1984"(Things go better with Coke 14). This was the first flavor change since the existence of the Coca-Cola company. The change was announced April 23, 1985 at the Vivian Beaumont Theater at the Lincoln Center. Some two hundred TV and newspaper reporters attended this very glitzy announcement. It included a question and answer session, a history of Coca-Cola, and many other elements(Oliver 131). The debut was accompanied by an advertising campaign that revived the Coca-Cola theme song of the early 1970s, "I'd Like to Buy the World a Coke"(Say it ain't so, Coke 24). The Jingle read like this: I'd like to teach the world

Biomarkers Definition Working Group

Biomarkers Definition Working Group With diminishing success in drug development, manufacturers have been exploring new ways of making drug manufacturing process successful. Biomarkers play a crucial role in drug development (Bleavins, Carini, Jurima, Rahbari, 2011). Pharmaceutical companies consider using biomarkers to increase the efficiency of new drugs. This paper explores biomarkers, their use, classifications and importance in drug development.Advertising We will write a custom essay sample on Biomarkers Definition Working Group specifically for you for only $16.05 $11/page Learn More Biomarker has various definitions from different groups. According to Biomarkers Definition Working Group, a it is defined as an indicator in pathogenic or biological processes, which can be measured and evaluated objectively in a given intervention in therapy (Bleavins et al., 2011). Clinical end point defines it as an indicator reflecting the feelings and functioning of a patient as well as his survival. Finally, surrogate endpoint defines biomarker, as an instrument whose intention is to substitute clinical end point (Bleavins et al., 2011). There are three types of biomarkers: type 0, I and II. Type 0 is an indicator in diseases and correlates with given symptoms. It is concerned with risks of a given exposure. Type I shows the effects or response of a given intervention or therapy in an organism during drug development. Type II biomarkers are surrogate indicators. This means that, change in a biomarker indicates clinical end (Bleavins et al., 2011). Biomarkers are used to measure the well-being of a person; both physical and mental. They are used to determine the state of an individual’s health (Zwierzina, 2008). In addition, they are used to measure the risks and influence of a given exposure, which can be as a result of environmental or hereditary factors. If a disease is caused by exposure to toxins, researchers may choose to measure the level of toxin concentration in an individuals environment. Researchers can also measure the alleged toxin in food, water, air or soil directly. As a result, they are able to ascertain the risks and susceptibility associated with a given exposure (Zwierzina, 2008). Biomarkers are used to ascertain the severity of diseases. They can determine whether a disease is severe or not. Biomarkers are used to predict results. They are used in drug development; hence they can predict the efficacy of a new drug.Advertising Looking for essay on health medicine? Let's see if we can help you! Get your first paper with 15% OFF Learn More In addition, they are used in determining the most efficient type of nutrition, intervention and treatment in a patient. Imaging a biomarker assists researchers to develop efficient drugs for a given disease; through evaluation of an individual and the response to the drug (Javitt Spencer, Thaker, Winterer, Hajà ³s, 2008). Post-therapy evaluation determines the efficie ncy of nutrition and intervention in an individuals body. Biomarkers are used to evaluate a persons response to therapy. Through biomarker imaging, the concentration of drugs in tissues can be measured (Javitt et al., 2008). In addition, receptor occupancy and characterization of receptors can be done to evaluate an individuals response towards an intervention. Biomarkers are used to monitor compliance of a drug. They are supposed to meet the intended purpose and adhere to given regulations. To determine the compliance of a drug, indicators are set in order to measure the biological activity of a drug before and after treatment. Biomarkers are used for forensic purposes (Wagner, 2008). They are applied in various fields of science and technology to establish facts about civil law. Generally, they are used for diverse purposes in clinical development. Different types of biomarkers are used for different purposes; hence they are unique and each has a specific purpose. For example, if a biomarker is intended to measure the effect of a drug or therapy, the response should show some correlations to the symptoms of disease (Wagner, 2008). Biomarkers are used according to their classifications; pharmacological, toxicological and pathological biomarkers. Indicators used for pathological processes are specific and can not be used for toxicological or pharmacological processes. In clinical care, biomarkers are classified according to their purpose (Javitt et al., 2008). Preventive biomarker identifies an individual’s risk to suffer from a certain disease. Diagnostic indicators are used to identify disease at early stages before the symptoms are noticed. Moreover, prognostic biomarkers show the possibility of disease progression in a patient as he continues with therapy.Advertising We will write a custom essay sample on Biomarkers Definition Working Group specifically for you for only $16.05 $11/page Learn More Also, there are predictive variables which identify the response of patient to a given therapy (Zwierzina, 2008). Lastly, therapeutic indicators give the total number of responses from patients undergoing a treatment. This means that each indicator is unique and has a set purpose. Biomarkers are identified according to their function. For example, if a researcher suspects that a disease is caused by being exposed to a certain toxin, then biomarkers (organisms) are exposed to these toxins and extend of effects is established. In oncology, the indicators for cancer are tumors and a researcher scans their sizes to determine the magnitude of an infection (Bleavins et al., 2011). Neurologists measure the occurrence of multiple sclerosis in order to evaluate Alzheimer disease. X-ray is done to establish the impacts of muscuskeletal diseases like arthritis and fractures among others. If the purpose of a biomarker is to measure the response of a given intervention, then an organism is subjected to a certain medicine. Different diseases have different biomarkers, for example, tumors are biomarkers for cancer (Bleavins et al., 2011). A surrogate endpoint can be defined as an indicator which alternates a clinical endpoint. It is also known as reserve biomarker. Clinical endpoint is an indicator showing the general operation of a patient. For example, blood pressure may not affect every patient, however in clinical development, it is considered as a risk factor for diseases like stroke and heart attack (Javitt et al., 2008). Pharmacodynamic markers are indicators used in monitoring biological impacts of a drug. They are used in decision- making during the early stages of drug development. They are used to establish doses and dosing in pre-clinical and clinical development of a drug. Pharmacodynamic marker is a reflection of pharmacologic responses (Wagner, 2008). Surrogate end point and Pharmacodynamic are useful in drug development. Surrogate end point is not an independent marker on itself. It ca n be extrinsic or intrinsic. It is a substitute. Moreover, they can be used in prediction of expected clinical results in drug development process (Wagner, 2008).Advertising Looking for essay on health medicine? Let's see if we can help you! Get your first paper with 15% OFF Learn More The main disadvantage of surrogate end points is: they need long follow ups and they are not independent. Pharmacodynamic are induced by non-drug events and have many limitations (Bleavins et al., 2011). One of the reasons these two biomarkers are not important in studies is surrogates are not a pathway for disease process in clinical developments. In addition, they are not sensitive to a given intervention. This means that they might give false impression about an intervention. Surrogates are important when a given process is well- known and the results expected are certain (Bleavins et al., 2011). Validation of surrogates is somehow difficult. They are important in some clinical developments but not all. Due to these reasons, surrogate and Pharmacodynamic biomarkers are not emphasized in studies. References Bleavins, M. R., Carini, C., Jurima-Romet, M., Rahbari, R. (Eds.). (2011). Biomarkers  in drug development: a handbook of practice, application, and strategy. Wiley. Javitt, D. C., Spencer, K. M., Thaker, G. K., Winterer, G., Hajà ³s, M. (2008). Neurophysiological biomarkers for drug development in schizophrenia. Nature Reviews Drug Discovery, 7(1), 68-83. Wagner, J. A. (2008). Strategic approach to fit-for-purpose biomarkers in drug development. Annu. Rev. Pharmacol. Toxicol., 48, 631-651. Zwierzina, H. (2008). Biomarkers in drug development. Annals of oncology, 19(suppl 5), v33-v37.

HMNT Ripple Effect Essay Example | Topics and Well Written Essays - 250 words

HMNT Ripple Effect - Essay Example Other positive effects of popular culture include ability to create positive role models, draw the line between good and bad and deliver this understandable message to wide masses without a doubt that the majority will get everything rights. Popular culture is controlled by authorities who serve as censors; they label content, ban it or ask to modify it if needed. There are legal definitions for obscenity, indecency and profanity that create certain legal frame for content creators (Obscenity, Indecency and Profanity: Its Against the Law). In some sense, popular culture controls society telling what to like and what to do. Also, it unifies people who come from different backgrounds and makes it easier for them to live together. Even though there are still many ongoing discussions about gender portrayals in art (Onstad, 2008) and racist messages (Vedantam, 2008), they depict a great progression in liberal though compared to what was popular 20 or even 10 years ago. Since popular culture is created by people, it is obvious that society has a great influence on it. Culture is the reflection of society of its creators; attitudes, moods, events, trends, roles and even political situations serve as factors of influence. Culture influences people in response popularizing certain ideas, spreading information, depicting changes and introducing new ideas to all. In this way, society and culture influence each other; they co-exist in complex relationships and change together. Vedantam, S. (2008, March 24).Unequal perspectives hyperlink "http://proquest.umi.com.ezp.waldenulibrary.org/pqdweb?did=1450200881&sid=4&fmt=3&clientid=70192&rqt=309&vname=pqd"onhyperlink "http://proquest.umi.com.ezp.waldenulibrary.org/pqdweb?did=1450200881&sid=4&fmt=3&clientid=70192&rqt=309&vname=pqd" racial equalityhyperlink "http://proquest.umi.com.ezp.waldenulibrary.org/pqdweb?did=1450200881&sid=4&fmt=3&clientid=70192&rqt=309&vname=pqd".The Washington Post,HYPERLINK